Structural-functional connectivity deficits of neocortical circuits in the Fmr1 mouse model of autism
نویسندگان
چکیده
INSERM, Neurocentre Magendie, Physiopathologie de la plasticité neuronale, U862, 33077 Bordeaux, France. University of Bordeaux, Neurocentre Magendie, Physiopathologie de la plasticité neuronale, U862, 33076 Bordeaux, France. Institute of NeuroInformatics, University of Zurich, 8057 Zurich, Switzerland. Biomedical MR Research Group, Department of Radiology and Nuclear Medicine, Radboud University Medical Center, 6500 Nijmegen, Netherlands. *Present address: National Center for Microscopy and Imaging Research, Center for Research in Biological Systems, University of California San Diego, School of Medicine, La Jolla, CA 92093, USA. †Present address: Neural Control of Movement Lab, Department of Health Sciences and Technology, ETH Zürich, 8057 Zurich, Switzerland. ‡Corresponding author. E-mail: [email protected]
منابع مشابه
Structural-functional connectivity deficits of neocortical circuits in the Fmr1 (-/y) mouse model of autism.
Fragile X syndrome (FXS), the most common inherited form of intellectual disability disorder and a frequent cause of autism spectrum disorder (ASD), is characterized by a high prevalence of sensory symptoms. Perturbations in the anatomical connectivity of neocortical circuits resulting in their functional defects have been hypothesized to contribute to the underlying etiology of these disorders...
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Despite the pronounced neurological deficits associated with mental retardation and autism, it is unknown if altered neocortical circuit function occurs in these prevalent disorders. Here, we demonstrate specific alterations in local synaptic connections, membrane excitability, and circuit activity of defined neuron types in sensory neocortex of the mouse model of Fragile X Syndrome – the Fmr1 ...
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Despite the pronounced neurological deficits associated with mental retardation and autism, it is unknown if altered neocortical circuit function occurs in these prevalent disorders. Here we demonstrate specific alterations in local synaptic connections, membrane excitability, and circuit activity of defined neuron types in sensory neocortex of the mouse model of Fragile X Syndrome-the Fmr1 kno...
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Despite the pronounced neurological deficits associated with mental retardation and autism, the degree to which neocortical circuit function is altered remains unknown. Here, we study changes in neocortical network function in the form of persistent activity states in the mouse model of fragile X syndrome--the Fmr1 knock-out (KO). Persistent activity states, or UP states, in the neocortex under...
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This study focused on the cytoarchitectonic and morphological differences in GABA-releasing interneurons between adult Fmr1 knock-out (FMR1KO) and wild-type (WT) mice in the somatosensory cortex. Our results showed a robust reorganization of neocortical, but not hippocampal inhibitory circuits in the FMR1KO mouse. The reorganization is characterized by a significant reduction (20%, p<0.001) in ...
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